The prevalence of biofilms in chronic wounds: a systematic review and meta-analysis of published data
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Date
2017-01
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Abstract
The presence of biofilms in chronic non-healing wounds, has been identified
through in vitro model and in vivo animal data. However, human chronic wound
studies are under-represented and generally report low sample sizes. For this
reason we sought to ascertain the prevalence of biofilms in human chronic wounds
by undertaking a systematic review and meta-analysis. Our initial search
identified 554 studies from the literature databases (Cochrane Library, Embase,
Medline). After removal of duplicates, and those not meeting the requirements of
inclusion, nine studies involving 185 chronic wounds met the inclusion criteria.
Prevalence of biofilms in chronic wounds was 78.2 % (confidence interval [CI
61.6-89, p<0.002]). The results of our meta-analysis support our clinical
assumptions that biofilms are ubiquitous in human chronic non-healing wounds.
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Malone M, Barjnsholt T, McBain AJ, James GA, Stoodley P, Leaper D, Tachi M, Shultz G, Swanson T, Wolcott RD “The prevalence of biofilms in chronic wounds: A systematic review and meta-analysis of published data” Journal of Wound Care, 2017 Jan 2;26(1):20-25.