Intracellular distribution of macrophage targeting ferritin–iron oxide nanocomposite
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Date
2009-01
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Abstract
Intracellular distribution of iron oxide nanoparticlesincorporated within a ferritin mutant that displays genetically introduced cell-targeted peptides (RGD-4C) on its exterior surface are investigated using scanning transmission electron microscopy with a high-angle annular dark-field detector. The particles (indicated by arrows) internalized into macrophages much more effectively than those with noncell-targeted ferritin.
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Uchida M, Willits DA, Muller K, Willis AF, Jackiw L, Jutila M, Young MJ, Porter AE, Douglas T, "Intracellular distribution of macrophage targeting ferritin–iron oxide nanocomposite," Adv. Mater. 2009 21(4):458-462