Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm
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Date
2009-05
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Abstract
Fluorescently-tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.
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Stewart PS, Davison WM, Steenbergen JN, "Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm," Antimicrob. Agents Chemother. 2009 53 (8):3505-3507