Biofilms strike back
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Date
2005-11
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Abstract
Excessive use of antibiotics has increased resistance of many microbes to these drugs. In a recent issue of Nature, Hoffman et al.1 show that too little antibiotic can also be detrimental. They demonstrated that subinhibitory levels of the aminoglycoside-class antibiotic tobramycin increase biofilm formation by various isolates of the bacterial pathogen Pseudomonas aeruginosa. This finding may lead to new therapies against persistent infections stemming from biofilm formation.
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O'Toole GA, Stewart PS, "Biofilms strike back," Nat Biotechnol, 2005 23(11):1378-1379