The Department of Cell Biology and Neuroscience provides pre-professional undergraduate students with a foundation of biological knowledge that prepares them for pursuit of careers in medicine and medically-related fields, biotechnology, biological research, biology teaching, and other related professions. It provides MSU undergraduates with an understanding of basic biology sufficient to insure informed participation in society, and trains, through our Ph.D. program, a new generation of biological scientists equipped to exploit advanced experimental and computational approaches to develop comprehensive understandings of complex biological systems. It aims to develop, through research, new knowledge in several key areas of cell biology and neuroscience.

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Recent Submissions

  • The Familial Dysautonomia disease gene, Ikbkap/Elp1, is required in the developing and adult central nervous system 

    Chaverra, Marta; George, Lynn; Mergy, Marc; Waller, Hannah; Kujawa, Katharine; Murnion, Connor; Sharples, Ezekiel; Thorne, Julian; Podgajny, Nathaniel; Grindeland, Andrea; Ueki, Yumi; Eiger, Steven; Cusick, Cassie; Babcock, A. Michael; Carlson, George A.; Lefcort, Frances (2017-02)
    Hereditary sensory and autonomic neuropathies (HSANs) are a genetically and clinically diverse group of disorders defined by peripheral nervous system (PNS) dysfunction. HSAN Type III, Familial Dysautonomia (FD), results ...
  • Experimental observation of phase-flip transitions in the brain 

    Dotson, Nicholas M; Gray, Charles M (2016-10)
    The phase-flip transition has been demonstrated in a host of coupled nonlinear oscillator models, many pertaining directly to understanding neural dynamics. However, there is little evidence that this phenomenon occurs in ...
  • The Drosophila prage Gene, Required for Maternal Transcript Destabilization in Embryos, Encodes a Predicted RNA Exonuclease 

    Cui, Jun; Lai, Yun Wei; Sartain, Caroline V.; Zuckerman, Rebecca M.; Wolfner, Mariana F. (2016-06)
    Egg activation, the transition of mature oocytes into developing embryos, is critical for the initiation of embryogenesis. This process is characterized by resumption of meiosis, changes in the egg's coverings and by ...
  • Quantification of dopaminergic neuron differentiation and neurotoxicity via a genetic reporter. 

    Cui, Jun; Rotstein, Megan; Bennett, Theo; Zhangm, Pengbo; Xia, Ninuo; Reijo Pera, Renee A. (2016-04)
    Human pluripotent stem cells provide a powerful human-genome based system for modeling human diseases in vitro and for potentially identifying novel treatments. Directed differentiation of pluripotent stem cells produces ...
  • TrkB/BDNF signalling patterns the sympathetic nervous system 

    Kasemeier-Kulesa, Jennifer S.; Morrison, Jason A.; Lefcort, Frances; Kulesa, Paul M. (2015-09)
    The sympathetic nervous system is essential for maintaining mammalian homeostasis. How this intricately connected network, composed of preganglionic neurons that reside in the spinal cord and post-ganglionic neurons that ...
  • Voltage-sensing phosphatase modulation by a C2 domain 

    Castle, Paul M.; Zolman, Kevin D.; Kohout, Susy C. (2015-04)
    The voltage-sensing phosphatase (VSP) is the first example of an enzyme controlled by changes in membrane potential. VSP has four distinct regions: the transmembrane voltage-sensing domain (VSD), the inter-domain linker, ...
  • Non-Invasive Quantification of Cartilage Using a Novel In Vivo Bioluminescent Reporter Mouse 

    Mailhiot, Sarah E.; Zignego, Donald L.; Prigge, Justin R.; Wardwell, Ella R.; Schmidt, Edward E.; June, Ron K. (2015-07)
    Mouse models are common tools for examining post-traumatic osteoarthritis (OA), which involves cartilage deterioration following injury or stress. One challenge to current mouse models is longitudinal monitoring of the ...
  • From dinosaurs to birds: a tail of evolution 

    Rashid, Dana; Chapman, Susan; Larsson, Hans; Organ, Chris; Merzdorf, Christa; Bradley, Roger; Horner, Jack (2014-05)
    A particularly critical event in avian evolution was the transition from long- to short-tailed birds. Primitive bird tails underwent significant alteration, most notably reduction of the number of caudal vertebrae and ...
  • X chromosome inactivation: recent advances and a look forward 

    Reijo Pera, Renee A.; Briggs, Sharon F. (Elsevier, 2014-10)
    X chromosome inactivation, the transcriptional inactivation of one X chromosome in somatic cells of female mammals, has revealed important advances in our understanding of development, epigenetic control, and RNA biology. ...