Efficacy of zosteric acid sodium salt on the yeast biofilm model Candida albicans

dc.contributor.authorVilla, Federica
dc.contributor.authorStewart, Philip S.
dc.contributor.authorGiussani, Barbara
dc.contributor.authorRoncoroni, S.
dc.contributor.authorAlbanese, Domenico
dc.contributor.authorGiordano, C.
dc.contributor.authorTunesi, M.
dc.contributor.authorCappitelli, Francesca
dc.date.accessioned2017-02-07T18:05:40Z
dc.date.available2017-02-07T18:05:40Z
dc.date.issued2011-05
dc.description.abstractCandida albicans is the most notorious and the most widely studied yeast biofilm former. Design of experiments (DoE) showed that 10 mg/L zosteric acid sodium salt reduced C. albicans adhesion and the subsequent biofilm formation by at least 70%, on both hydrophilic and hydrophobic surfaces of 96-well plates. Indeed, biofilm imaging revealed the dramatic impact of zosteric acid sodium salt on biofilm thickness and morphology, due to the inability of the cells to form filamentous structures while remaining metabolically active. In the same way, 10 mg/L zosteric acid sodium salt inhibited C. albicans biofilm formation when added after the adhesion phase. Contrary to zosteric acid sodium salt, methyl zosterate did not affect yeast biofilm. In addition, zosteric acid sodium salt enhanced sensitivity to chlorhexidine, chlorine, hydrogen peroxide, and cis-2-decenoic acid, with a reduction of 0.5 to 8 log units. Preliminary in vitro studies using suitable primary cell based models revealed that zosteric acid sodium salt did not compromise the cellular activity, adhesion, proliferation or morphology of either the murine fibroblast line L929 or the human osteosarcoma line MG-63. Thus the use of zosteric acid sodium salt could provide a suitable, innovative, preventive, and integrative approach to preventing yeast biofilm formation.en_US
dc.identifier.citationVilla F, Pitts B, Stewart PS, Giussani B, Roncoroni S, Albanese D, Giordano C, Tunesi M, Cappitelli F, "Efficacy of zosteric acid sodium salt on the yeast biofilm model Candida albicans," Microbial Ecology 2011 62(3):584–598en_US
dc.identifier.issn0095-3628
dc.identifier.urihttps://scholarworks.montana.edu/handle/1/12576
dc.titleEfficacy of zosteric acid sodium salt on the yeast biofilm model Candida albicansen_US
dc.typeArticleen_US
mus.citation.extentfirstpage584en_US
mus.citation.extentlastpage598en_US
mus.citation.issue3en_US
mus.citation.journaltitleMicrobial Ecologyen_US
mus.citation.volume62en_US
mus.contributor.orcidStewart, Philip S.|0000-0001-7773-8570en_US
mus.data.thumbpage12en_US
mus.identifier.categoryChemical & Material Sciencesen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1007/s00248-011-9876-xen_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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