Lactose-functionalized PAMAM Dendrimer Effects on Cancer cell Aggregation

Abstract

The interaction of galectin-3 with a lactose-functionalized PAMAM dendrimer is monitored through aggregation assays with the human cancer cell lines HT-1080 and A-549. It is hypothesized and shown that the generation-2 dendrimer (relatively small) will inhibit aggregation (Figure 3.6 a). Also hypothesized is that the larger dendrimers will induce aggregation by aiding in cross-linking of cells (Figure 3.6 b), but results are inconclusive.