Kaiser, Coleen R.Flenniken, Michelle L.Gillitzer, EricHarmsen, Ann L.Harmsen, Allen G.Jutila, Mark A.Douglas, TrevorYoung, Mark J.2019-02-132019-02-132007-12Kaiser, Coleen R., Michelle L. Flenniken, Eric Gillitzer, Ann L. Harmsen, Allen G. Harmsen, Mark A. Jutila, Trevor Douglas, Mark J. Young (2007). Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo. International Journal of Nanomedicine, 2 (4), 713-733.1178-2013https://scholarworks.montana.edu/handle/1/15262Protein cage nanoparticles have the potential to serve as multifunctional cell targeted, imaging and therapeutic platforms for broad applications in medicine. However, before they find applications in medicine, their biocompatibility in vivo needs to be demonstrated. We provide here baseline biodistribution information of two different spherical protein cage nanoplatforms, the 28 nm viral Cowpea chlorotic mottle virus (CCMV) and the 12 nm heat shock protein (Hsp) cage. In naïve and immunized mice both nanoplatforms show similar broad distribution and movement throughout most tissues and organs, rapid excretion, the absence of long term persistence within mice tissue and organs, and no overt toxicity after a single injection. These results suggest that protein cage based nanoparticles may serve as safe, biocompatible, nanoplatforms for applications in medicine.enCC BY: This license lets you distribute, remix, tweak, and build upon this work, even commercially, as long as you credit the original creator for this work. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.https://creativecommons.org/licenses/by/4.0/legalcodeArticle