O'Toole, George A.Stewart, Philip S.2017-07-132017-07-132005-11O'Toole GA, Stewart PS, "Biofilms strike back," Nat Biotechnol, 2005 23(11):1378-13791087-0156https://scholarworks.montana.edu/handle/1/13307Excessive use of antibiotics has increased resistance of many microbes to these drugs. In a recent issue of Nature, Hoffman et al.1 show that too little antibiotic can also be detrimental. They demonstrated that subinhibitory levels of the aminoglycoside-class antibiotic tobramycin increase biofilm formation by various isolates of the bacterial pathogen Pseudomonas aeruginosa. This finding may lead to new therapies against persistent infections stemming from biofilm formation.Article