Stankevich, Ksenia S.Kudryavtseva, Valeriya L.Bolbasov, Evgeny N.Shesterikov, Evgeny V.Larionova, Irina V.Shapovalova, Yelena G.Domracheva, Liubov V.Volokhova, Apollinariya A.Kurzina, Irina A.Zhukov, Yuri M.Malashicheva, Anna B.Kzhyshkowska, Julia G.Tverdokhlebov, Sergei I.2022-03-042022-03-042020Ksenia S. Stankevich, Valeriya L. Kudryavtseva, Evgeny N. Bolbasov, Evgeny V. Shesterikov, Irina V. Larionova, Yelena G. Shapovalova, Liubov V. Domracheva, Apollinariya A. Volokhova, Irina A. Kurzina, Yuri M. Zhukov, Anna B. Malashicheva, Julia G. Kzhyshkowska, and Sergei I. Tverdokhlebov, ACS Biomaterials Science & Engineering 2020 6 (7), 3967-3974 DOI: 10.1021/acsbiomaterials.0c004402373-9878https://scholarworks.montana.edu/handle/1/16682Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly(ε-caprolactone) (PCL) scaffolds. However, the PCL chemical bonding state, the composition of the deposited coating, and their interaction with immune cells remain unknown. Herein, we demonstrated that the DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogen-containing moieties and the titanium dioxide coating on the scaffold surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of the titanium target could be an effective tool to control macrophage functional responses toward PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.en-USThis document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Biomaterials Science & Engineering, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsbiomaterials.0c00440Article