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  • Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection 

    Hashimi, Marziah; Sebrell, T. Andrew; Hedges, Jodi F.; Snyder, Deann; Lyon, Katrina N.; Byrum, Stephanie D.; Mackintosh, Samuel G.; Crowley, Dan; Cherne, Michelle D.; Skwarchuk, David; Robison, Amanda; Sidar, Barkan; Kunze, Anja; Loveday, Emma K.; Taylor, Matthew P.; Chang, Connie B.; Wilking, James N.; Walk, Seth T.; Schountz, Tony; Jutila, Mark A.; Bimczok, Diane (Springer Science and Business Media LLC, 2023-10)
    Bats are natural reservoirs for several zoonotic viruses, potentially due to an enhanced capacity to control viral infection. However, the mechanisms of antiviral responses in bats are poorly defined. Here we established ...
  • Discovering unknown associations between prokaryotic receptors and their ligands 

    Dlakić, Mensur (Proceedings of the National Academy of Sciences, 2023-11)
    The motility of microorganisms through the environment is driven by chemical gradients: They move towards nutrients and away from signals that indicate unfavorable conditions. This chemotaxis is mediated by transmembrane ...
  • Genome sequence, phylogenetic analysis, and structure-based annotation reveal metabolic potential of Chlorella sp. SLA-04 

    Goemann, Calvin L.C.; Wilkinson, Royce; Henriques, William; Bui, Huyen; Goemann, Hannah M.; Carlson, Ross P.; Viamajala, Sridhar; Gerlach, Robin; Wiedenheft, Blake (Elsevier BV, 2023-01)
    Algae are a broad class of photosynthetic eukaryotes that are phylogenetically and physiologically diverse. Most of the phylogenetic diversity has been inferred from 18S rDNA sequencing since there are only a few complete ...
  • Development of potent isoflavone-based formyl peptide receptor 1 (FPR1) antagonists and their effects in gastric cancer cell models 

    Francavilla, Fabio; Sarcina, Federica; Schepetkin, Igor A.; Kirpotina, Lilya N.; Contino, Marialessandra; Schirizzi, Annalisa; De Leonardis, Giampiero; Khlebnikov, Andrei I.; D'Alessandro, Rosalba; Quinn, Mark T.; Lacivita, Enza; Leopoldo, Marcello (Elsevier BV, 2023-12)
    Formyl peptide receptor-1 (FPR1) is a G protein-coupled chemoattractant receptor that plays a crucial role in the trafficking of leukocytes into the sites of bacterial infection and inflammation. Recently, FPR1 was shown ...
  • Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia 

    Plotnikov, Mark B.; Chernysheva, Galina A.; Smol’yakova, Vera I.; Aliev, Oleg I.; Anishchenko, Anna M.; Ulyakhina, Olga A.; Trofimova, Eugene S.; Ligacheva, Anastasia A.; Anfinogenova, Nina D.; Osipenko, Anton N.; Kovrizhina, Anastasia R.; Khlebnikov, Andrei I.; Schepetkin, Igor A.; Drozd, Anastasia G.; Plotnikov, Evgenii V.; Atochin, Dmitriy N.; Quinn, Mark T. (MDPI AG, 2023-07)
    The activation of c-Jun N-terminal kinase (JNK) plays an important role in stroke outcomes. Tryptanthrin-6-oxime (TRYP-Ox) is reported to have high affinity for JNK and anti-inflammatory activity and may be of interest as ...
  • Immunomodulatory Activity of Polysaccharides Isolated from Saussurea salicifolia L. and Saussurea frolovii Ledeb 

    Schepetkin, Igor A.; Danilets, Marina G.; Ligacheva, Anastasia A.; Trofimova, Evgenia S.; Selivanova, Natalia S.; Sherstoboev, Evgenii Yu.; Krivoshchekov, Sergei V.; Gulina, Ekaterina I.; Brazovskii, Konstantin S.; Kirpotina, Liliya N.; Quinn, Mark T.; Belousov, Mikhail V. (MDPI AG, 2023-09)
    The genus Saussurea has been used in the preparation of therapies for a number of medical problems, yet not much is known about the therapeutic high-molecular-weight compounds present in extracts from these plants. Since ...
  • Comparative Aerosol and Surface Stability of SARS-CoV-2 Variants of Concern 

    Bushmaker, Trenton; Kwe Yinda, Claude; Morris, Dylan H.; Holbrook, Myndi G.; Gamble, Amandine; Adney, Danielle; Bushmaker, Cara; van Doremalen, Neeltje; Fischer, Robert J.; Plowright, Raina K.; Lloyd-Smith, James O.; Munster, Vincent J. (Centers for Disease Control and Prevention, 2023-05)
    SARS-CoV-2 transmits principally by air; contact and fomite transmission may also occur. Variants of concern are more transmissible than ancestral SARS-CoV-2. We found indications of possible increased aerosol and surface ...
  • Vasoactive and Neuroprotective Effects of c-Jun N-Terminal Kinase Inhibitor in Rats with Chronic Cerebral Hypoperfusion 

    Zhilyaev, S. Yu.; Platonova, T. F.; Khlebnikov, A. I.; Demchenko, I. T.; Atochin, D. N. (Pleiades Publishing Ltd, 2023-05)
    The aim of this study was to evaluate the vasoactive and neuroprotective effects of c-Jun N-terminal kinase inhibitor IQ-1 (11H-indeno[1,2-b]quinoxalin-11-one oxime) in chronic cerebral hypoperfusion caused by irreversible ...
  • Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors 

    Schepetkin, Igor A.; Karpenko, Oleksander S.; Kovrizhina, Anastasia R.; Kirpotina, Liliya N.; Khlebnikov, Andrei I.; Chekal, Stepan I.; Radudik, Alevtyna V.; Shybinska, Maryna O.; Quinn, Mark T. (MDPI AG, 2023-06)
    The c-Jun N-terminal kinase (JNK) family includes three proteins (JNK1-3) that regulate many physiological processes, including cell proliferation and differentiation, cell survival, and inflammation. Because of emerging ...
  • Functional and Phylogenetic Diversity of Cas10 Proteins 

    Wiegand, Tanner; Wilkinson, Royce; Santiago-Frangos, Andrew; Lynes, Mackenzie; Hatzenpichler, Roland; Wiedenheft, Blake (Mary Ann Liebert Inc, 2023-04)
    Cas10 proteins are large subunits of type III CRISPR RNA (crRNA)-guided surveillance complexes, many of which have nuclease and cyclase activities. Here, we use computational and phylogenetic methods to identify and analyze ...
  • Virtually the Same? Evaluating the Effectiveness of Remote Undergraduate Research Experiences 

    Hess, Riley A.; Erickson, Olivia A.; Cole, Rebecca B.; Isaacs, Jared M.; Alvarez-Clare, Silvia; Arnold, Jonathan; Augustus-Wallace, Allison; Ayoob, Joseph C.; Berkowitz, Alan; Branchaw, Janet; Burgio, Kevin R.; Cannon, Charles H.; Ceballos, Ruben Michael; Cohen, C. Sarah; Coller, Hilary; Disney, Jane; Doze, Van A.; Eggers, Margaret J.; Ferguson, Edwin L.; Gray, Jeffrey J.; Greenberg, Jean T.; Hoffmann, Alexander; Jensen-Ryan, Danielle; Kao, Robert M.; Keene, Alex C.; Kowalkoc, Johanna E.; Lopez, Steven A.; Mathis, Camille; Minkara, Mona; Murren, Courtney J.; Ondrechen, Mary Jo; Ordoñez, Patricia; Osano, Anne; Padilla-Crespo, Elizabeth; Palchoudhury, Soubantika; Qin, Hong; Ramírez-Lugo, Juan; Reithel, Jennifer; Shaw, Colin A.; Smith, Amber; Smith, Rosemary J.; Tsien, Fern; Dolan, Erin L. (American Society for Cell Biology, 2023-06)
    In-person undergraduate research experiences (UREs) promote students’ integration into careers in life science research. In 2020, the COVID-19 pandemic prompted institutions hosting summer URE programs to offer them remotely, ...
  • Genome sequence, phylogenetic analysis, and structure-based annotation reveal metabolic potential of Chlorella sp. SLA-04 

    Goemann, Calvin L.C.; Wilkinson, Royce; Henriques, William; Bui, Huyen; Goemann, Hannah M.; Carlson, Ross P.; Viamajala, Sridhar; Gerlach, Robin; Wiedenheft, Blake (Elsevier BV, 2023-01)
    Algae are a broad class of photosynthetic eukaryotes that are phylogenetically and physiologically diverse. Most of the phylogenetic diversity has been inferred from 18S rDNA sequencing since there are only a few complete ...
  • Inhibition of Acetylcholinesterase by Novel Lupinine Derivatives 

    Schepetkin, Igor A.; Nurmaganbetov, Zhangeldy S.; Fazylov, Serik D.; Nurkenov, Oralgazy A.; Khlebnikov, Andrei I.; Seilkhanov, Tulegen M.; Kishkentaeva, Anarkul S.; Shults, Elvira E.; Quinn, Mark T. (MDPI AG, 2023-04)
    Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment due in part to a severe loss of cholinergic neurons in specific brain areas. AD is the most common ...
  • Cumulative stressful events and mental health in young adults after 10 years of Wenchuan earthquake: the role of social support 

    Chen, Xiao-Yan; Wang, Dongfang; Liu, Xianchen; Shi, Xuliang; Scherffius, Andrew; Fan, Fang (Informa UK Limited, 2023-03)
    Background: After a natural disaster, stressful events often continue to accumulate, affecting individuals in a different manner than the original disaster never occurred. However, few studies have examined these associations, ...
  • Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction 

    Plotnikov, Mark B.; Chernysheva, Galina A.; Smol’yakova, Vera I.; Aliev, Oleg I.; Fomina, Tatyana I.; Sandrikina, Lyubov A.; Sukhodolo, Irina V.; Ivanova, Vera V.; Osipenko, Anton N.; Anfinogenova, Nina D.; Khlebnikov, Andrei I.; Atochin, Dmitriy N.; Schepetkin, Igor A.; Quinn, Mark T. (MDPI AG, 2023-02)
    Activation of c-Jun N-terminal kinases (JNKs) is involved in myocardial injury, left ventricular remodeling (LV), and heart failure (HF) after myocardial infarction (MI). The aim of this research was to evaluate the effects ...
  • Comparison of Enrichment and Plating Media for Recovery of Virulent Strains of Yersinia enterocolitica from Inoculated Beef Stew 

    Schiemann, D.A. (Elsevier BV, 1983-11)
    Five plating agar media were evaluated for their ability to recover pure cultures of virulent strains of Yersinia enterocolitica serotypes O:3, O:8 and O:5,27. Cellobiose-arginine-lysine and bismuth sulfite agars were ...
  • Relationships between fluid mixing, biodiversity, and chemosynthetic primary productivity in Yellowstone hot springs 

    Fernandes‐Martins, Maria C.; Colman, Daniel R.; Boyd, Eric S. (Wiley, 2023-01)
    The factors that influence biodiversity and productivity of hydrothermal ecosystems are not well understood. Here we investigate the relationship between fluid mixing, biodiversity, and chemosynthetic primary productivity ...
  • A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life 

    Wu, Sheng-Yi; Wen, Yurong; Serre, Nelson B. C.; Heiede Laursen, Cathrine Charlotte; Grostøl Dietz, Andrea; Taylor, Brian R.; Drobizhev, Mikhail; Molina, Rosana S.; Aggarwal, Abhi; Rancic, Vladimir; Becker, Michael; Ballanyi, Klaus; Podgorski, Kaspar; Hirase, Hajime; Nedergaard, Maiken; Fendrych, Matyáš; Lemieux, M. Joanne; Eberl, Daniel F.; Kay, Alan R.; Campbell, Robert E.; Shen, Yi (Public Library of Science, 2022-09)
    Potassium ion (K+) plays a critical role as an essential electrolyte in all biological systems. Genetically-encoded fluorescent K+ biosensors are promising tools to further improve our understanding of K+-dependent processes ...
  • Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury 

    Shearn, Colin T.; Anderson, Aimee L.; Miller, Colin G.; Noyd, Reed C.; Devereaux, Michael W.; Balasubramaniyan, Nata; Orlicky, David J.; Schmidt, Edward E.; Sokol, Ronald J. (Ovid Technologies, 2023-01)
    Background and Aims: Cholestatic liver diseases, including primary sclerosing cholangitis, are characterized by periportal inflammation with progression to hepatic fibrosis and ultimately cirrhosis. We recently reported ...
  • The Pseudomonas aeruginosa RpoH (σ32) Regulon and Its Role in Essential Cellular Functions, Starvation Survival, and Antibiotic Tolerance 

    Williamson, Kerry S.; Dlakić, Mensur; Akiyama, Tatsuya; Franklin, Michael J. (MDPI AG, 2023-01)
    The bacterial heat-shock response is regulated by the alternative sigma factor, σ32 (RpoH), which responds to misfolded protein stress and directs the RNA polymerase to the promoters for genes required for protein refolding ...

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