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dc.contributor.advisorChairperson, Graduate Committee: Michael Babcocken
dc.contributor.authorCoombs, Katie Marieen
dc.description.abstractThe neuronal glutamate transporter EAAC1 (EAAT3) is present in hippocampal neurons to prevent excessive glutamate accumulation. Glutamate receptor-dependent synaptic plasticity is important for learning and memory. The present study investigates behavior associated with blocking the glutamate transporter EAAC1. To manipulate EAAC1 function, rats were intrahippocampally injected with a adeno-associated viral (AAV) vector encoding an EAAC1 antisense mRNA sequence or an AAV empty cassette. Twenty-eight days following surgery, rats were tested in a delayed matching-to-place (DMTP) watermaze task to examine spatial memory, which is hippocampaldependent. Rats treated with EAAC1 antisense exhibited shorter latencies to locate the target platform relative to controls (p < 0.05). These data indicate that microinfusion of AAV encoding EAAC1 antisense significantly altered performance on task involving glutamate transmission and the hippocampus.en
dc.publisherMontana State University - Bozeman, College of Letters & Scienceen
dc.subject.lcshGlutamate decarboxylaseen
dc.subject.lcshHippocampus (Brain)en
dc.titleBehavioral consequences following AAV mediated hippocampal EAAC1 knockdownen
dc.rights.holderCopyright 2007 by Katie Marie Coombsen
thesis.catalog.ckey1286516en, Graduate Committee: Keith Hutchison; Wesley Lynchen

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