Show simple item record

dc.contributor.advisorChairperson, Graduate Committee: Michael Babcocken
dc.contributor.authorCoombs, Katie Marieen
dc.date.accessioned2013-06-25T18:37:19Z
dc.date.available2013-06-25T18:37:19Z
dc.date.issued2007en
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/1104en
dc.description.abstractThe neuronal glutamate transporter EAAC1 (EAAT3) is present in hippocampal neurons to prevent excessive glutamate accumulation. Glutamate receptor-dependent synaptic plasticity is important for learning and memory. The present study investigates behavior associated with blocking the glutamate transporter EAAC1. To manipulate EAAC1 function, rats were intrahippocampally injected with a adeno-associated viral (AAV) vector encoding an EAAC1 antisense mRNA sequence or an AAV empty cassette. Twenty-eight days following surgery, rats were tested in a delayed matching-to-place (DMTP) watermaze task to examine spatial memory, which is hippocampaldependent. Rats treated with EAAC1 antisense exhibited shorter latencies to locate the target platform relative to controls (p < 0.05). These data indicate that microinfusion of AAV encoding EAAC1 antisense significantly altered performance on task involving glutamate transmission and the hippocampus.en
dc.language.isoenen
dc.publisherMontana State University - Bozeman, College of Letters & Scienceen
dc.subject.lcshMemoryen
dc.subject.lcshTestingen
dc.subject.lcshGlutamate decarboxylaseen
dc.subject.lcshHippocampus (Brain)en
dc.titleBehavioral consequences following AAV mediated hippocampal EAAC1 knockdownen
dc.typeThesisen
dc.rights.holderCopyright 2007 by Katie Marie Coombsen
thesis.catalog.ckey1286516en
thesis.degree.committeemembersMembers, Graduate Committee: Keith Hutchison; Wesley Lynchen
thesis.degree.departmentPsychology.en
thesis.degree.genreThesisen
thesis.degree.nameMSen
thesis.format.extentfirstpage1en
thesis.format.extentlastpage51en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record


MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.