Show simple item record

dc.contributor.authorChihara, Kotaro
dc.contributor.authorMatsumoto, Shinya
dc.contributor.authorKagawa, Yuki
dc.contributor.authorTsuneda, Satoshi
dc.date.accessioned2016-11-14T23:40:30Z
dc.date.available2016-11-14T23:40:30Z
dc.date.issued2015-05
dc.identifier.citationChihara K, Matsumoto S, Kagawa Y, Tsuneda S, ʺMathematical modeling of dormant cell formation in growing biofilm,ʺ Front Microbiol. 2015 May 28 6:534.en_US
dc.identifier.issn1664-302X
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/11504
dc.description.abstractUnderstanding the dynamics of dormant cells in microbial biofilms, in which the bacteria are embedded in extracellular matrix, is important for developing successful antibiotic therapies against pathogenic bacteria. Although some of the molecular mechanisms leading to bacterial persistence have been speculated in planktonic bacterial cell, how dormant cells emerge in the biofilms of pathogenic bacteria such as Pseudomonas aeruginosa remains unclear. The present study proposes four hypotheses of dormant cell formation; stochastic process, nutrient-dependent, oxygen-dependent, and time-dependent processes. These hypotheses were implemented into a three-dimensional individual-based model of biofilm formation. Numerical simulations of the different mechanisms yielded qualitatively different spatiotemporal distributions of dormant cells in the growing biofilm. Based on these simulation results, we discuss what kinds of experimental studies are effective for discriminating dormant cell formation mechanisms in biofilms.en_US
dc.rightsCC BY 4.0en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcodeen_US
dc.titleMathematical modeling of dormant cell formation in growing biofilmen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage8en_US
mus.citation.journaltitleFrontiers in Microbiologyen_US
mus.citation.volume6en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.categoryPhysics & Mathematicsen_US
mus.identifier.doi10.3389/fmicb.2015.00534en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.departmentMathematical Sciences.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.data.thumbpage5en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0

MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.