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dc.contributor.authorKeil, Deborah E.
dc.contributor.authorBuck, Brenda
dc.contributor.authorGoossens, Dirk
dc.contributor.authorTeng, Yuanxin
dc.contributor.authorLeetham, M.
dc.contributor.authorMurphy, Lacey M.
dc.contributor.authorPollard, James
dc.contributor.authorEggers, Margaret J.
dc.contributor.authorMcLaurin, Brett
dc.contributor.authorGerads, Russell
dc.contributor.authorDeWitt, Jamie C.
dc.date.accessioned2016-11-29T17:37:24Z
dc.date.available2016-11-29T17:37:24Z
dc.date.issued2016-01
dc.identifier.citationSIGN IN 2016 Department Contributions Comments Share FileEditViewInsertFormatDataToolsAdd-onsHelpAll changes saved in Drive $% 123 Calibri 11 More Keil D, Buck B, Goossens D, Teng Y, Leetham M, Murphy L, Pollard J, Eggers M, McLaurin B, Gerads R, DeWitt J, "Immunotoxicological and neurotoxicological profile of health effects following subacute exposure to geogenic dust from sand dunes at the Nellis Dunes Recreation Area, Las Vegas, NV," Toxicol Appl Pharmacol. 2016 Jan 15 291:1-12. To enable screen reader support, press shortcut Ctrl+Alt+Z. To learn about keyboard shortcuts, press shortcut Ctrl+slash. CBE JJCBE Explore Keil D, Buck B, Goossens D, Teng Y, Leetham M, Murphy L, Pollard J, Eggers M, McLaurin B, Gerads R, DeWitt J, "Immunotoxicological and neurotoxicological profile of health effects following subacute exposure to geogenic dust from sand dunes at the Nellis Dunes Recreation Area, Las Vegas, NV," Toxicol Appl Pharmacol. 2016 Jan 15 291:1-12.en_US
dc.identifier.issn0041-008X
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/12262
dc.description.abstractExposure to geogenic particulate matter (PM) comprised of mineral particles has been linked to human health effects. However, very little data exist on health effects associated with geogenic dust exposure in natural settings. Therefore, we characterized particulate matter size, metal chemistry, and health effects of dust collected from the Nellis Dunes Recreation Area (NDRA), a popular off-road vehicle area located near Las Vegas, NV. Adult female B6C3F1 mice were exposed to several concentrations of mineral dust collected from active and vegetated sand dunes in NDRA. Dust samples (median diameter: 4.4 μm) were suspended in phosphate-buffered saline and delivered at concentrations ranging from 0.01 to 100 mg dust/kg body weight by oropharyngeal aspiration. ICP-MS analyses of total dissolution of the dust resulted in aluminum (55,090 μg/g), vanadium (70 μg/g), chromium (33 μg/g), manganese (511 μg/g), iron (21,600 μg/g), cobalt (9.4 μg/g), copper (69 μg/g), zinc (79 μg/g), arsenic (62 μg/g), strontium (620 μg/g), cesium (13 μg/g), lead 25 μg/g) and uranium (4.7 μg/g). Arsenic was present only as As(V). Mice received four exposures, once/week over 28-days to mimic a month of weekend exposures. Descriptive and functional assays to assess immunotoxicity and neurotoxicity were performed 24 h after the final exposure. The primary observation was that 0.1 to 100 mg/kg of this sand dune derived dust dose-responsively reduced antigen-specific IgM antibody responses, suggesting that dust from this area of NDRA may present a potential health risk.en_US
dc.description.sponsorshipU.S. Bureau of Land Management (L11AC20058)en_US
dc.titleImmunotoxicological and neurotoxicological profile of health effects following subacute exposure to geogenic dust from sand dunes at the Nellis Dunes Recreation Area, Las Vegas, NVen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage12en_US
mus.citation.journaltitleToxicology and Applied Pharmacologyen_US
mus.citation.volume291en_US
mus.identifier.categoryChemical & Material Sciencesen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.doi10.1016/j.taap.2015.11.020en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.collegeCollege of Education, Health & Human Developmenten_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCell Biology & Neuroscience.en_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentHealth & Human Development.en_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.data.thumbpage2en_US
mus.contributor.orcidKeil, Deborah E.|0000-0002-5787-8514en_US


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