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dc.contributor.authorPerez-Diaz, M. A.
dc.contributor.authorBoegli, Laura
dc.contributor.authorJames, Garth A.
dc.contributor.authorVelasquillo, C.
dc.contributor.authorSanchez-Sanchez, R.
dc.contributor.authorMartinez-Martinez, R. E.
dc.contributor.authorMartinez-Castanon, G. A.
dc.contributor.authorMartinez-Gutierrez, F.
dc.identifier.citationPérez-Díaz MA, Boegli L, James G, Velasquillo C, Sánchez-Sánchez R, Martínez-Martínez RE, Martínez-Castañón GA, Martinez-Gutierrez F, "Silver nanoparticles with antimicrobial activities against Streptococcus mutans and their cytotoxic effect," Materials Science and Engineering: C 55 (October 2015): 360–366. doi:10.1016/j.msec.2015.05.036.en_US
dc.description.abstractMicrobial resistance represents a challenge for the scientific community to develop new bioactive compounds. The goal of this research was to evaluate the antimicrobial activity of silver nanoparticles (AgNPs) against a clinical isolate of Streptococcus mutans, antibiofilm activity against mature S. mutans biofilms and the compatibility with human fibroblasts. The antimicrobial activity of AgNPs against the planktonic clinical isolate was size and concentration dependent, with smaller AgNPs having a lower minimum inhibitory concentration. A reduction of 2.3 log in the number of colony-forming units of S. mutans was observed when biofilms grown in a CDC reactor were exposed to 100 ppm of AgNPs of 9.5 ± 1.1 nm. However, AgNPs at high concentrations (> 10 ppm) showed a cytotoxic effect upon human dermal fibroblasts. AgNPs effectively inhibited the growth of a planktonic S. mutans clinical isolate and killed established S. mutans biofilms, which suggests that AgNPs could be used for prevention and treatment of dental caries. Further research and development are necessary to translate this technology into therapeutic and preventive strategies.en_US
dc.description.sponsorshipConsejo Nacional de Ciencia y Tecnología (233241); Sistema Nacional de Investigadores (SNI 48199); PROMEP (103.5/12/7965)en_US
dc.titleSilver nanoparticles with antimicrobial activities against Streptococcus mutans and their cytotoxic effecten_US
mus.citation.journaltitleMaterials Science and Engineering: Cen_US
mus.identifier.categoryChemical & Material Sciencesen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.collegeCollege of Education, Health & Human Developmenten_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentHealth & Human Development.en_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

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