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    Aggregatibacter actinomycetemcomitans biofilm killing by a targeted ciprofloxacin prodrug

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    Date
    2013-09
    Author
    Reeves, Benjamin D.
    Young, Mark J.
    Grieco, Paul A.
    Suci, Peter A.
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    Abstract
    A pH-sensitive ciprofloxacin prodrug was synthesized and targeted against biofilms of the periodontal pathogen Aggregatibacter actinomycetemcomitans (Aa). The dose required to reduce the viability of a mature biofilm of Aa by ∼80% was in the range of ng cm−2 of colonized area (mean biofilm density 2.33 × 109 cells cm−2). A mathematical model was formulated that predicts the temporal change in the concentration of ciprofloxacin in the Aa biofilm as the drug is released and diffuses into the bulk medium. The predictions of the model were consistent with the extent of killing obtained. The results demonstrate the feasibility of the strategy to induce mortality, and together with the mathematical model, provide the basis for design of targeted antimicrobial prodrugs for the topical treatment of oral infections such as periodontitis. The targeted prodrug approach offers the possibility of optimizing the dose of available antimicrobials in order to kill a chosen pathogen while leaving the commensal microbiota relatively undisturbed.
    URI
    https://scholarworks.montana.edu/xmlui/handle/1/12407
    DOI
    10.1080/08927014.2013.823541
    Citation
    Reeves BD, Young M, Grieco PA, Suci P, "Aggregatibacter actinomycetemcomitans biofilm killing by a targeted ciprofloxacin prodrug," Biofouling Sep 2013 29(8):1005-1014
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    • Scholarly Work - Plant Sciences & Plant Pathology
    • Scholarly Work - Center for Biofilm Engineering

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