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dc.contributor.authorLindley, B.
dc.contributor.authorWang, Qi
dc.contributor.authorZhang, Tian-Yu
dc.identifier.citationLindley B, Wang Q, Zhang TY, "A multicomponent model for biofilm-drug interaction," Discrete and Continuous Dynamical Systems–Series B, March 2011 15(2):417–456.en_US
dc.description.abstractWe developed a tri-component model for the biofilm and solvent mixture, in which the extracellular polymeric substance (EPS) network, bacteria and effective solvent consisting of the solvent, nutrient, drugs, etc., are modeled explicitly. The tri-component mixture is assumed incompressible as a whole, while inter-component mixing, dissipation, and conversion are allowed.A linear stability analysis is conducted on constant equilibria revealing up to two unstable modes corresponding to possible bacterial growth induced by the bacterial and EPS production and dependent upon the regime of the model parameters. A 1-D transient simulation is carried out to investigate the non-linear dynamics of the EPS network, bacteria distribution, drug and nutrient distribution in a channel with and without shear. Finally, the transient biofilm dynamics are studied with respect to a host of diffusive properties of the drug and nutrient present in the biofilm.en_US
dc.titleA multicomponent model for biofilm-drug interactionen_US
mus.citation.journaltitleDiscrete and Continuous Dynamical Systems–Series Ben_US
mus.identifier.categoryChemical & Material Sciencesen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.departmentHealth & Human Development.en_US
mus.relation.departmentMathematical Sciences.en_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

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