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dc.contributor.authorMoraski, Garrett C.
dc.contributor.authorCheng, Yong
dc.contributor.authorCho, Sanghyun
dc.contributor.authorCramer, Jeffrey W
dc.contributor.authorGodfrey, Alexander
dc.contributor.authorMasquelin, Thierry
dc.contributor.authorFranzblau, Scott G.
dc.contributor.authorMiller, Marvin J.
dc.contributor.authorSchorey, Jeffery
dc.date.accessioned2017-02-14T23:03:56Z
dc.date.available2017-02-14T23:03:56Z
dc.date.issued2016-08
dc.identifier.citationMoraski, Garrett C, Yong Cheng, Sanghyun Cho, Jeffrey W Cramer, Alexander Godfrey, Thierry Masquelin, Scott G Franzblau, Marvin J Miller, and Jeffery Schorey. "Imidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivo.." Antimicrobial Agents and Chemotherapy 60, no. 8 (August 2016): 5018-5022. DOI:https://dx.doi.org/10.1128/AAC.00618-16.en_US
dc.identifier.issn1098-6596
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/12605
dc.description.abstractA panel of six imidazo[1,2-a]pyridine-3-carboxamides (IAPs) were shown to have low-micromolar activity against Mycobacterium avium strains. Compound ND-10885 (compound 2) showed significant activity in the lung, spleen, and liver in a mouse M. avium infection model. A combined regimen consisting of ND-10885 (compound 2) and rifampin was additive in its anti-M. avium activity in the lung. Our data indicate that IAPs represent a new class of antibiotics that are active against M. avium and could potentially serve as an effective addition to a combined treatment regimen.en_US
dc.description.sponsorshipNSF (CHE-0741793)en_US
dc.language.isoen_USen_US
dc.titleImidazo[1,2-a]Pyridine-3-Carboxamides Are Active Antimicrobial Agents against Mycobacterium avium Infection In Vivoen_US
dc.typeArticleen_US
mus.citation.extentfirstpage5018en_US
mus.citation.extentlastpage5022en_US
mus.citation.issue8en_US
mus.citation.journaltitleAntimicrobial Agents and Chemotherapyen_US
mus.citation.volume60en_US
mus.identifier.categoryChemical & Material Sciencesen_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.doihttps://dx.doi.org/10.1128/AAC.00618-16en_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentChemistry & Biochemistry.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage15en_US
mus.contributor.orcidMoraski, Garrett C.|0000-0002-6992-5584en_US


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