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dc.contributor.authorVickova, Klara
dc.contributor.authorGomez, Andres
dc.contributor.authorWhittier, Christopher A.
dc.contributor.authorTodd, Angelique F.
dc.contributor.authorYeoman, Carl J.
dc.contributor.authorNelson, Karen E.
dc.contributor.authorWilson, Brenda A.
dc.contributor.authorStumpf, Rebecca M.
dc.contributor.authorModry, David
dc.contributor.authorWhite, Bryan A.
dc.contributor.authorLeigh, Steven R.
dc.date.accessioned2017-04-13T19:22:27Z
dc.date.available2017-04-13T19:22:27Z
dc.date.issued2016-11
dc.identifier.citationVlckova, Klara, Andres Gomez, Klara J Petrzelkova, Christopher A Whittier, Angelique F Todd, Carl J Yeoman, Karen E Nelson, Brenda A Wilson, Rebecca M Stumpf, David Modry, Bryan A White, and Steven R Leigh. "Effect of Antibiotic Treatment on the Gastrointestinal Microbiome of Free-Ranging Western Lowland Gorillas (Gorilla g. gorilla)." Microbial Ecology 72, no. 4 (November 2016): 943-954. DOI: 10.1007/s00248-016-0745-5.en_US
dc.identifier.issn1432-184X
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/12725
dc.description.abstractThe mammalian gastrointestinal (GI) microbiome, which plays indispensable roles in host nutrition and health, is affected by numerous intrinsic and extrinsic factors. Among them, antibiotic (ATB) treatment is reported to have a significant effect on GI microbiome composition in humans and other animals. However, the impact of ATBs on the GI microbiome of free-ranging or even captive great apes remains poorly characterized. Here, we investigated the effect of cephalosporin treatment (delivered by intramuscular dart injection during a serious respiratory outbreak) on the GI microbiome of a wild habituated group of western lowland gorillas (Gorilla gorilla gorilla) in the Dzanga Sangha Protected Areas, Central African Republic. We examined 36 fecal samples from eight individuals, including samples before and after ATB treatment, and characterized the GI microbiome composition using Illumina-MiSeq sequencing of the bacterial 16S rRNA gene. The GI microbial profiles of samples from the same individuals before and after ATB administration indicate that the ATB treatment impacts GI microbiome stability and the relative abundance of particular bacterial taxa within the colonic ecosystem of wild gorillas. We observed a statistically significant increase in Firmicutes and a decrease in Bacteroidetes levels after ATB treatment. We found disruption of the fibrolytic community linked with a decrease of Ruminoccocus levels as a result of ATB treatment. Nevertheless, the nature of the changes observed after ATB treatment differs among gorillas and thus is dependent on the individual host. This study has important implications for ecology, management, and conservation of wild primates.en_US
dc.description.sponsorshipInternal Grant Agency of University of Veterinary and Pharmaceutical Sciences Brno; Institute of Vertebrate Biology, Academy of Sciences of the Czech Republic (RVO 68081766);European Social Fund; State Budget of the Czech Republic; US NSFen_US
dc.language.isoen_USen_US
dc.titleEffect of Antibiotic Treatment on the Gastrointestinal Microbiome of Free-Ranging Western Lowland Gorillas (Gorilla g. gorilla)en_US
dc.typeArticleen_US
mus.citation.extentfirstpage943en_US
mus.citation.extentlastpage954en_US
mus.citation.issue4en_US
mus.citation.journaltitleMicrobial Ecologyen_US
mus.citation.volume72en_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1007/s00248-016-0745-5en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.departmentAnimal & Range Sciences.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage8en_US


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