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dc.contributor.authorVenters, Michael
dc.contributor.authorCarlson, Ross P.
dc.contributor.authorGedeon, Tomas
dc.contributor.authorHeys, Jeffrey J.
dc.date.accessioned2017-05-12T18:37:21Z
dc.date.available2017-05-12T18:37:21Z
dc.date.issued2017-01
dc.identifier.citationVenters, Michael, Ross P Carlson, Thomas Gedeon, and Jeffrey J Heys. "Effects of Spatial Localization on Microbial Consortia Growth." PloS One 12, no. 1 (January 2017): e0168592. DOI:https://dx.doi.org/10.1371/journal.pone.0168592 .en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/12819
dc.description.abstractMicrobial consortia are commonly observed in natural and synthetic systems, and these consortia frequently result in higher biomass production relative to monocultures. The focus here is on the impact of initial spatial localization and substrate diffusivity on the growth of a model microbial consortium consisting of a producer strain that consumes glucose and produces acetate and a scavenger strain that consumes the acetate. The mathematical model is based on an individual cell model where growth is described by Monod kinetics, and substrate transport is described by a continuum-based, non-equilibrium reaction-diffusion model where convective transport is negligible (e.g., in a biofilm). The first set of results focus on a single producer cell at the center of the domain and surrounded by an initial population of scavenger cells. The impact of the initial population density and substrate diffusivity is examined. A transition is observed from the highest initial density resulting in the greatest cell growth to cell growth being independent of initial density. A high initial density minimizes diffusive transport time and is typically expected to result in the highest growth, but this expected behavior is not predicted in environments with lower diffusivity or larger length scales. When the producer cells are placed on the bottom of the domain with the scavenger cells above in a layered biofilm arrangement, a similar critical transition is observed. For the highest diffusivity values examined, a thin, dense initial scavenger layer is optimal for cell growth. However, for smaller diffusivity values, a thicker, less dense initial scavenger layer provides maximal growth. The overall conclusion is that high density clustering of members of a food chain is optimal under most common transport conditions, but under some slow transport conditions, high density clustering may not be optimal for microbial growth.en_US
dc.description.sponsorshipNSF (DMS 1361240)en_US
dc.language.isoen_USen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcodeen_US
dc.titleEffects of Spatial Localization on Microbial Consortia Growthen_US
dc.typeArticleen_US
mus.citation.extentfirstpagee0168592en_US
mus.citation.extentlastpagee0168592en_US
mus.citation.issue1en_US
mus.citation.journaltitlePloS Oneen_US
mus.citation.volume12en_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1371/journal.pone.0168592en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage4en_US
mus.contributor.orcidGedeon, Tomas|0000-0001-5555-6741en_US


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