Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections
Date
2017-01Author
Draughn, G. Logan
Allen, C. Leigh
Routh, Patricia A.
Stone, Maria R.
Kirker, Kelly R.
Boegli, Laura
Schuchman, Ryan M.
Linder, Keith E.
Baynes, Ronald E.
James, Garth A.
Melander, Christian
Pollard, Angela
Cavanagh, John
Metadata
Show full item recordAbstract
2-Aminoimidazole (2-AI)-based compounds have been shown to efficiently disrupt biofilm formation, disperse existing biofilms, and resensitize numerous multidrug-resistant bacteria to antibiotics. Using Pseudomonas aeruginosa and Staphylococcus aureus, we provide initial pharmacological studies regarding the application of a 2-AI as a topical adjuvant for persistent dermal infections. In vitro assays indicated that the 2-AI H10 is nonbactericidal, resensitizes bacteria to antibiotics, does not harm the integument, and promotes wound healing. Furthermore, in vivo application of H10 on swine skin caused no gross abnormalities or immune reactions. Taken together, these results indicate that H10 represents a promising lead dermal adjuvant compound.
Citation
Draughn, G. Logan, C. Leigh Allen, Patricia A. Routh, Maria R. Stone, Kelly R. Kirker, Laura Boegli, Ryan M. Schuchman, Keith E. Linder, Ronald E. Baynes, Garth James, Christian Melander, Angela Pollard, and John Cavanagh. "Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections." Drug Design Development and Therapy 11 (January 2017): 153-162. DOI:https://dx.doi.org/10.2147/DDDT.S111865.