dc.contributor.author Johnson, Timothy dc.date.accessioned 2017-06-02T22:03:23Z dc.date.available 2017-06-02T22:03:23Z dc.date.issued 2017-04 dc.identifier.uri https://scholarworks.montana.edu/xmlui/handle/1/12917 dc.description.abstract The original purpose of my research was to develop mathematical models of heat transfer and cell death and combine them into a model of Laser Tissue Welding (LTW) using collagen nanocomposite materials. LTW is an alternative to surgical sutures for repairing cuts and ruptures in tissues. Our LTW model uses collagen mixed with gold nanoparticles that convert light into heat. The application of laser light leads to a temporary phase change in the collagen from a gel to a viscous liquid and back into a gel that can seal a cut in the surrounding tissue. This topic interests me because as a student in Chemical Engineering, I will likely work with heat transfer and biological systems in many future projects. To develop the model, Dr. Jeff Heys and I utilized the Python programming language along with the FEniCS software library to solve the various partial differential equations and algebraic equations in the model. I combined two previously developed mathematical models: a bio-heat transfer model and a cell death model, and adapted them to work together in a single program so that individual variables can be optimized as efficiently as possible. Thus far, we have successfully integrated the two models into a single code that can predict the temperature of the nanocomposite and the surrounding tissue as well as predict the fraction of cells that are killed by elevated temperatures at different spatial locations. It is not yet possible to optimize system parameters, but is expected to be before May, 2017. en_US dc.language.iso en_US en_US dc.publisher Montana State University en_US dc.title Gold nano rod hydrogel nanocomposite laser tissue welding en_US dc.type Presentation en_US mus.citation.conference Student Research Celebration en_US mus.citation.extentfirstpage 1 en_US mus.citation.extentlastpage 1 en_US mus.relation.college College of Engineering en_US mus.relation.department Chemical & Biological Engineering. en_US mus.relation.university Montana State University - Bozeman en_US
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