Show simple item record

dc.contributor.authorYoung, Mark
dc.date.accessioned2017-06-05T16:53:10Z
dc.date.available2017-06-05T16:53:10Z
dc.date.issued2017-04
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/12961
dc.description.abstractThe purpose of this study was to rheologically characterize solutions by changing the concentration of hydroxypropyl methylcellulose acetate succinate (HPMCAS) dissolved in a variety of solvents, including acetone, methanol, and an acetone and water mixture. HPMCAS is a synthetic polymer derived from cellulose, it has found high interest in the pharmaceutical industry where it heavily used in the formation of spray-dried dispersion's. The characterization of the rheological properties of these solutions is of interest to better understand how the solvent choice and the polymer concentration impact the spray-dried dispersion. Polymer solutions exhibit critical concentrations of overlap and entanglement that correlate to when the polymer chains in solution begin to overlap with other chains and when polymers chains begin to entangle with other chains in the solution. When polymer chains overlap with each other a network forms in the solution, this leads to an increased viscosity as well as viscoelastic behavior that can be observed and characterized. Steady state flow tests, strain sweeps, and frequency sweeps were performed to observe the rheological properties of these polymer solutions. Overlap and entanglement concentrations were found for solutions with the solvents of Acetone, Methanol and an acetone and water mixture. The viscoelasticity of these solutions was then analyzed at polymer concentrations between and above these critical concentrations.en_US
dc.language.isoen_USen_US
dc.publisherMontana State Univeristyen_US
dc.titleRheological Characterization of HPMCAS in Various Solventsen_US
dc.typePresentationen_US
mus.citation.conferenceStudent Research Celebrationen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage1en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record


MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.