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dc.contributor.authorKirker, Kelly R.
dc.contributor.authorJames, Garth A.
dc.date.accessioned2017-06-13T19:56:19Z
dc.date.available2017-06-13T19:56:19Z
dc.date.issued2017-04
dc.identifier.citationKirker KR, James GA, “In vitro studies evaluating the effects of biofilms on wound-healing cells: a review,” APMIS, 2017 April; 125(4):344-352. doi: 10.1111/apm.12678.en_US
dc.identifier.issn0903-4641
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/13059
dc.description.abstractChronic wounds are characterized as wounds that have failed to proceed through the well-orchestrated healing process and have remained open for months to years. Open wounds are at risk for colonization by opportunistic pathogens. Bacteria that colonize the open wound bed form surface-attached, multicellular communities called biofilms, and chronic wound biofilms can contain a diverse microbiota. Investigators are just beginning to elucidate the role of biofilms in chronic wound pathogenesis, and have simplified the complex wound environment using in vitro models to obtain a fundamental understanding of the impact of biofilms on wound-healing cell types. The intent of this review is to describe current in vitro methodologies and their results. Investigations started with one host cell-type and single species biofilms and demonstrated that biofilms, or their secretions, had deleterious effects on wound-healing cells. More complex systems involved the use of multiple host cell/tissue types and single species biofilms. Using human skin-equivalent tissues, investigators demonstrated that a number of different species can grow on the tissue and elicit an inflammatory response from the tissue. A full understanding of how biofilms impact wound-healing cells and host tissues will have a profound effect on how chronic wounds are treated.en_US
dc.titleIn vitro studies evaluating the effects of biofilms on wound-healing cells: a reviewen_US
dc.typeArticleen_US
mus.citation.extentfirstpage344en_US
mus.citation.extentlastpage352en_US
mus.citation.issue4en_US
mus.citation.journaltitleAPMISen_US
mus.citation.volume125en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1111/apm.12678en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.data.thumbpage5en_US


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