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dc.contributor.authorLeid, Jeff G.
dc.contributor.authorShirtliff, Mark E.
dc.contributor.authorCosterton, J. William
dc.contributor.authorStoodley, Paul
dc.identifier.citationLeid JG, Shirtliff ME, Costerton JW, and Stoodley P, "Human leukocytes adhere, penetrate, and respond to Staphylococcus aureus biofilms," Infect & Immun, 70(11): 6339-6345 (2002).en_US
dc.description.abstractStaphylococcus aureus is a common pathogen responsible for nosocomial and community infections. It readily colonizes indwelling catheters, forming microbiotic communities termed biofilms. S. aureus bacteria in biofilms are protected from killing by antibiotics and the body's immune system. For years, one mechanism behind biofilm resistance to attack from the immune system's sentinel leukocytes has been conceptualized as a deficiency in the ability of the leukocytes to penetrate the biofilm. We demonstrate here that under conditions mimicking physiological shear, leukocytes attach, penetrate, and produce cytokines in response to maturing and fully matured S. aureus biofilm.en_US
dc.titleHuman leukocytes adhere, penetrate, and respond to Staphylococcus aureus biofilmsen_US
mus.citation.journaltitleInfection and Immunityen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.contributor.orcidStoodley, Paul|0000-0001-6069-273Xen_US

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