Show simple item record

dc.contributor.authorBerra, Lorenzo
dc.contributor.authorKolobow, Theodor
dc.contributor.authorLaquerriere, Patrice
dc.contributor.authorPitts, Betsey
dc.contributor.authorBramati, Simone
dc.contributor.authorPohlmann, Joshua
dc.contributor.authorMarelli, Chiara
dc.contributor.authorPanzeri, Miriam
dc.contributor.authorBrambillasca, Pietro
dc.contributor.authorVilla, Federica
dc.contributor.authorBaccarelli, Andrea
dc.contributor.authorBouthors, Sylvie
dc.contributor.authorStelfox, Henry T.
dc.contributor.authorBigatello, Luca M.
dc.contributor.authorMoss, Joel
dc.contributor.authorPesenti, Antonio
dc.identifier.citationBerra L, Kolobow T, Laquerriere P, Pitts B, Bramati S, Pohlmann J, Marelli C, Panzeri M, Brambillasca P, Villa F, Baccarelli A, Bouthors S, H.T. Stelfox HT, Bigatello LM, Moss J, Pesenti A, "Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: A clinical trial," Intensive Care Med. 2008 34(6):1030-1037en_US
dc.description.abstractOBJECTIVE: Coated medical devices have been shown to reduce catheter-related infections. We coated endotracheal tubes (ETT) with silver sulfadiazine (SSD), and tested them in a clinical study to assess the feasibility, safety, and efficacy of preventing bacterial colonization. DESIGN: A prospective, randomized clinical trial, phase I-II. SETTING: Academic intensive care unit (ICU). PARTICIPANTS: Forty-six adult patients expected to need 12-24 h of intubation were randomized into two groups. INTERVENTIONS: Patients were randomized to be intubated with a standard non-coated ETT (St-ETT, n = 23; control group), or with a SSD-coated ETT (SSD-ETT, n = 23). MEASUREMENTS AND RESULTS: Coating with SSD prevented bacterial colonization of the ETT (frequency of colonization: SSD-ETT 0/23, St-ETT 8/23; p < 0.01). No organized bacterial biofilm could be identified on the lumen of any ETT; however, SSD was associated with a thinner mucus layer (in the SSD-ETT secretion deposits ranged from 0 to 200 µm; in the St-ETT deposits ranged between 50 and 700 µm). No difference was observed between the two groups in the tracheobronchial brush samples (frequency of colonization: SSD-ETT 0/23, St-ETT 2/23; p = 0.48). No adverse reactions were observed with the implementation of the novel device. CONCLUSION: SSD-ETT can be safely used in preventing bacterial colonization and narrowing of the ETT in patients intubated for up to 24 h (mean intubation time 16h).en_US
dc.titleInternally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: A clinical trialen_US
mus.citation.journaltitleIntensive Care Medicineen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.