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dc.contributor.authorHolman, Hoi-Ying N.
dc.contributor.authorWozei, Eleanor
dc.contributor.authorLin, Zhang
dc.contributor.authorComolli, Luis R.
dc.contributor.authorBall, David A.
dc.contributor.authorBorglin, Sharon
dc.contributor.authorFields, Matthew W.
dc.contributor.authorHazen, Terry C.
dc.contributor.authorDowning, Kenneth H.
dc.identifier.citationHolman HYN, Wozeia E, Lin Z, Comolli LR, Ball DA, Borglin S, Fields MW, Hazen TC, Downing KH, "Real-time molecular monitoring of chemical environment in obligate anaerobes during oxygen adaptive response," Proceedings of the National Academy of Sciences 2009 106(31): 12599–12604en_US
dc.description.abstractDetermining the transient chemical properties of the intracellular environment can elucidate the paths through which a biological system adapts to changes in its environment, for example, the mechanisms that enable some obligate anaerobic bacteria to survive a sudden exposure to oxygen. Here we used high-resolution Fourier transform infrared (FTIR) spectromicroscopy to continuously follow cellular chemistry within living obligate anaerobes by monitoring hydrogen bond structures in their cellular water. We observed a sequence of well orchestrated molecular events that correspond to changes in cellular processes in those cells that survive, but only accumulation of radicals in those that do not. We thereby can interpret the adaptive response in terms of transient intracellular chemistry and link it to oxygen stress and survival. This ability to monitor chemical changes at the molecular level can yield important insights into a wide range of adaptive responses.en_US
dc.titleReal-time molecular monitoring of chemical environment in obligate anaerobes during oxygen adaptive responseen_US
mus.citation.journaltitleProceedings of the National Academy of Sciencesen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.contributor.orcidFields, Matthew W.|0000-0001-9053-1849en_US

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