Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm
Stewart, Philip S.
Davison, William M.
Steenbergen, J. N.
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Fluorescently-tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.
Stewart PS, Davison WM, Steenbergen JN, "Daptomycin rapidly penetrates a Staphylococcus epidermidis biofilm," Antimicrob. Agents Chemother. 2009 53 (8):3505-3507