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dc.contributor.authorDesrosiers, Martin
dc.contributor.authorMyntti, Matthew
dc.contributor.authorJames, Garth A.
dc.identifier.citationDesrosiers M, Myntti M, James G, "Methods for removing bacterial biofilms: In vitro study using clinical chronic rhinosinusitis specimens," Am J Rhinol 21(5): 527-532 (2007)en_US
dc.description.abstractBACKGROUND: Bacterial biofilms may be involved in refractory chronic rhinosinusitis (CRS).In vitro, we studied methods for removing biofilms formed by Staphylococcus aureus and Pseudomonas aeruginosa.METHODS: Bacterial isolates were obtained from patients with refractory CRS and were plated and treated with either static administration of citric acid/zwitterionic surfactant (CAZS), saline delivered with hydrodynamic force, or CAZS delivered hydrodynamically. Results were assessed by counting colony-forming units (CFUs) and by confocal scanning laser microscopy (CSLM). RESULTS: All treatments produced significant reductions in CFU counts (p >or= 0.002). Hydrodynamic CAZS provided the greatest reduction, decreasing CFU counts from control values by 3.9 +/- 0.3 logs and 5.2 +/- 0.5 logs for S. aureus and P. aeruginosa, respectively (99.9% reduction; p = 0.001). CSLM showed decreases in biofilm coverage.CONCLUSION: Hydrodynamic delivery of a soap-like surfactant and a calcium-ion sequestering agent may disrupt biofilms associated with CRS. Our results may be relevant to a new approach to refractory CRS.en_US
dc.titleMethods for removing bacterial biofilms: In vitro study using clinical chronic rhinosinusitis specimensen_US
mus.citation.journaltitleAmerican Journal of Rhinologyen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

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