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dc.contributor.authorKlapper, Isaac
dc.contributor.authorGilbert, P.
dc.contributor.authorAyati, B. P.
dc.contributor.authorDockery, Jack D.
dc.contributor.authorStewart, Philip S.
dc.identifier.citationKlapper I, Gilbert P, Ayati BP, Dockery J, Stewart PS, "Senescence can explain microbial persistence," Microbiology 2007 153(11):3623-3630en_US
dc.description.abstractIt has been known for many years that small fractions of persister cells resist killing in many bacterial colony–antimicrobial confrontations. These persisters are not believed to be mutants. Rather it has been hypothesized that they are phenotypic variants. Current models allow cells to switch in and out of the persister phenotype. Here, a different explanation is suggested for persistence, namely senescence. Using a mathematical model including age structure, it is shown that senescence provides a natural explanation for persistence-related phenomena, including the observations that the persister fraction depends on growth phase in batch culture and dilution rate in continuous culture.en_US
dc.titleSenescence can explain microbial persistenceen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.contributor.orcidStewart, Philip S.|0000-0001-7773-8570en_US

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