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dc.contributor.authorSuci, Peter A.
dc.contributor.authorBerglund, Deborah L.
dc.contributor.authorLiepold, Lars Otto
dc.contributor.authorBrumfield, Susan
dc.contributor.authorPitts, Betsey
dc.contributor.authorDavison, William M.
dc.contributor.authorOltrogge, Luke
dc.contributor.authorHoyt, Kathryn Olivia
dc.contributor.authorCodd, Sarah L.
dc.contributor.authorStewart, Philip S.
dc.contributor.authorYoung, Mark J.
dc.contributor.authorDouglas, Trevor
dc.identifier.citationSuci PA, Berglund DL, Liepold L, Brumfield LS, Pitts B, Davison W, Oltrogge L, Hoyt KO, Codd S, Stewart PS, Young M, Douglas T, "High-density targeting of a viral multifunctional nanoplatform to a pathogenic, biofilm-forming bacterium," Chem. Biol. 2007 14(4):387-398en_US
dc.description.abstractNanomedicine directed at diagnosis and treatment of infections can benefit from innovations that have substantially increased the variety of available multifunctional nanoplatforms. Here, we targeted a spherical, icosahedral viral nanoplatform to a pathogenic, biofilm-forming bacterium, Staphylococcus aureus. Density of binding mediated through specific protein-ligand interactions exceeded the density expected for a planar, hexagonally close-packed array. A multifunctionalized viral protein cage was used to load imaging agents (fluorophore and MRI contrast agent) onto cells. The fluorescence-imaging capability allowed for direct observation of penetration of the nanoplatform into an S. aureus biofilm. These results demonstrate that multifunctional nanoplatforms based on protein cage architectures have significant potential as tools for both diagnosis and targeted treatment of recalcitrant bacterial infections.en_US
dc.titleHigh-density targeting of a viral multifunctional nanoplatform to a pathogenic, biofilm-forming bacteriumen_US
mus.citation.journaltitleChemistry & Biologyen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.contributor.orcidStewart, Philip S.|0000-0001-7773-8570en_US

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