Show simple item record

dc.contributor.authorFux, C. A.
dc.contributor.authorQuigley, Mark
dc.contributor.authorWorel, A. M.
dc.contributor.authorPost, C.
dc.contributor.authorZimmerli, S.
dc.contributor.authorEhrlich, Garth D.
dc.contributor.authorVeeh, Richard Harold
dc.identifier.citationFux CA, Quigley M, Worel AM, Post C, Zimmerli S, Ehrlich G, Veeh RH, "Biofilm-related infections of cerebrospinal fluid shunts," Clin Microbiol Infect 2006 12(4):331-337en_US
dc.identifier.issn1198-743X To enable screen reader support, press Ctrl+Alt+Z To learn about keyboard shortcuts, press Ctrl+slash
dc.description.abstractCerebrospinal fluid (CSF) shunts carry a high risk of complications. Infections represent a major cause of shunt failure. Diagnosis and therapy of such infections are complicated by the formation of bacterial biofilms attached to shunt surfaces. This study correlated the pathophysiology and clinical course of biofilm infections with microscopic findings on the respective shunts. Surface irregularities, an important risk factor for shunt colonisation with bacteria, were found to increase over time because of silicone degradation. Scanning electron-microscopy (SEM) documented residual biological material (dead biofilm), which can further promote extant bacterial adhesion, on newly manufactured shunts. Clinical course, and SEM both documented bacterial dissemination against CSF flow and the monodirectional valve. In all cases, biofilms grew on both the inner and outer surfaces of the shunts. Microscopy and conventional culture detected all bacterial shunt infections. Analyses of 16S rDNA sequences using conserved primers identified bacteria in only one of three cases, probably because of previous formalin fixation of the samples.en_US
dc.titleBiofilm-related infections of cerebrospinal fluid shuntsen_US
mus.citation.journaltitleClinical Microbiology and Infectionen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record

MSU uses DSpace software, copyright © 2002-2017  Duraspace. For library collections that are not accessible, we are committed to providing reasonable accommodations and timely access to users with disabilities. For assistance, please submit an accessibility request for library material.