Biofilms strike back
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Excessive use of antibiotics has increased resistance of many microbes to these drugs. In a recent issue of Nature, Hoffman et al.1 show that too little antibiotic can also be detrimental. They demonstrated that subinhibitory levels of the aminoglycoside-class antibiotic tobramycin increase biofilm formation by various isolates of the bacterial pathogen Pseudomonas aeruginosa. This finding may lead to new therapies against persistent infections stemming from biofilm formation.
O'Toole GA, Stewart PS, "Biofilms strike back," Nat Biotechnol, 2005 23(11):1378-1379