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dc.contributor.authorAbdul Rani, Suriani
dc.contributor.authorPitts, Betsey
dc.contributor.authorStewart, Philip S.
dc.date.accessioned2017-07-20T15:42:46Z
dc.date.available2017-07-20T15:42:46Z
dc.date.issued2005-01
dc.identifier.citationAbdul Rani S, Pitts B, Stewart PS, "Rapid diffusion of fluorescent tracers into Staphylococcus epidermidis biofilms visualized by time lapse microscopy," Antimicrob Agents Chemother, 2005 49(2):728-732en_US
dc.identifier.issn0066-4804
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/13364
dc.description.abstractThe transient diffusion of fluorescent tracers into biofilm cell clusters of Staphylococcus epidermidis was visualized by time lapse confocal scanning laser microscopy. Rhodamine B diffused into the center of cell clusters that were 200 to 600 micron in diameter within a few minutes. The apparent effective diffusion coefficient calculated from these data averaged 3.7 x 10(-7) cm(2) s(-1) or 11% of the value in pure water. Fluorescein diffused into biofilm more rapidly, with a diffusion coefficient that averaged 1.6 x 10(-6) cm(2) s(-1), or 32% of the value in water. This study provides direct, visual confirmation that solutes the size of many antibiotics and biocides can diffuse rapidly into biofilms.en_US
dc.titleRapid diffusion of fluorescent tracers into Staphylococcus epidermidis biofilms visualized by time lapse microscopyen_US
dc.typeArticleen_US
mus.citation.extentfirstpage728en_US
mus.citation.extentlastpage732en_US
mus.citation.issue2en_US
mus.citation.journaltitleAntimicrobial Agents and Chemotherapyen_US
mus.citation.volume49en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1128/aac.49.2.728-732.2005en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.data.thumbpage2en_US
mus.contributor.orcidStewart, Philip S.|0000-0001-7773-8570en_US


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