Show simple item record

dc.contributor.authorFux, C. A.
dc.contributor.authorShirtliff, Mark E.
dc.contributor.authorStoodley, Paul
dc.contributor.authorCosterton, J. William
dc.date.accessioned2017-07-20T15:46:54Z
dc.date.available2017-07-20T15:46:54Z
dc.date.issued2005-02
dc.identifier.citationFux CA, Shirtliff M, Stoodley P, Costerton JW, "Can laboratory reference strains mirror 'real-world' pathogenesis?," Trends Microbiol, 2005 13(2):58-63en_US
dc.identifier.issn0966-842X
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/13365
dc.description.abstractThe extraordinary plasticity of bacterial genomes raises concerns about the adequacy of laboratory-adapted reference strains for the study of 'real world' pathogenesis. Some laboratory strains have been sub-cultured for decades since their first isolation and might have lost important pathophysiological characteristics. Evidence is presented that bacteria rapidly adapt to in vitro conditions. Genomic differences between laboratory reference strains and corresponding low-passage clinical isolates are reviewed. It appears that no bacterial strain can truly represent its species. For DNA microarray and proteomic studies, this limitation might be overcome by the summation of individual genomes to produce a species-specific virtual supragenome.en_US
dc.titleCan laboratory reference strains mirror 'real-world' pathogenesis?en_US
dc.typeArticleen_US
mus.citation.extentfirstpage58en_US
mus.citation.extentlastpage63en_US
mus.citation.issue2en_US
mus.citation.journaltitleTrends in Microbiologyen_US
mus.citation.volume13en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1016/j.tim.2004.11.001en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.data.thumbpage1en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record