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dc.contributor.authorFux, C. A.
dc.contributor.authorCosterton, J. William
dc.contributor.authorStewart, Philip S.
dc.contributor.authorStoodley, Paul
dc.date.accessioned2017-07-20T15:55:09Z
dc.date.available2017-07-20T15:55:09Z
dc.date.issued2005-01
dc.identifier.citationFux CA, Costerton JW, Stewart PS, Stoodley P, "Survival strategies of infectious biofilms," Trends Microbiol, 2005 13(1):34-40en_US
dc.identifier.issn0966-842X
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/13366
dc.description.abstractModern medicine is facing the spread of biofilm-related infections. Bacterial biofilms are difficult to detect in routine diagnostics and are inherently tolerant to host defenses and antibiotic therapies. In addition, biofilms facilitate the spread of antibiotic resistance by promoting horizontal gene transfer. We review current concepts of biofilm tolerance with special emphasis on the role of the biofilm matrix and the physiology of biofilm-embedded cells. The heterogeneity in metabolic and reproductive activity within a biofilm correlates with a non-uniform susceptibility of enclosed bacteria. Recent studies have documented similar heterogeneity in planktonic cultures. Nutritional starvation and high cell density, two key characteristics of biofilm physiology, also mediate antimicrobial tolerance in stationary-phase planktonic cultures. Advances in characterizing the role of stress response genes, quorum sensing and phase variation in stationary-phase planktonic cultures have shed new light on tolerance mechanisms within biofilm communities.en_US
dc.titleSurvival strategies of infectious biofilmsen_US
dc.typeArticleen_US
mus.citation.extentfirstpage34en_US
mus.citation.extentlastpage40en_US
mus.citation.issue1en_US
mus.citation.journaltitleTrends in Microbiologyen_US
mus.citation.volume13en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1016/j.tim.2004.11.010en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.data.thumbpage3en_US
mus.contributor.orcidStoodley, Paul|0000-0001-6069-273Xen_US
mus.contributor.orcidStewart, Philip S.|0000-0001-7773-8570en_US


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