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dc.contributor.authorDavis, Lisa
dc.contributor.authorGedeon, Tomas
dc.contributor.authorHeberling, Tamra
dc.contributor.authorGedeon, Jakub
dc.contributor.authorMorgan, Charles
dc.date.accessioned2017-08-08T13:59:19Z
dc.date.available2017-08-08T13:59:19Z
dc.date.issued2016-08
dc.identifier.issn1553-734X
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/13452
dc.description.abstractIn fast-transcribing prokaryotic genes, such as an rrn gene in Escherichia coli, many RNA polymerases (RNAPs) transcribe the DNA simultaneously. Active elongation of RNAPs is often interrupted by pauses, which has been observed to cause RNAP traffic jams; yet some studies indicate that elongation seems to be faster in the presence of multiple RNAPs than elongation by a single RNAP. We propose that an interaction between RNAPs via the torque produced by RNAP motion on helically twisted DNA can explain this apparent paradox. We have incorporated the torque mechanism into a stochastic model and simulated transcription both with and without torque. Simulation results illustrate that the torque causes shorter pause durations and fewer collisions between polymerases. Our results suggest that the torsional interaction of RNAPs is an important mechanism in maintaining fast transcription times, and that transcription should be viewed as a cooperative group effort by multiple polymerases.en_US
dc.titleA Mechanistic Model for Cooperative Behavior of Co-transcribing RNA Polymerasesen_US
dc.typeArticleen_US
mus.citation.issue8en_US
mus.citation.journaltitlePLOS Computational Biologyen_US
mus.citation.volume12en_US
mus.identifier.categoryPhysics & Mathematicsen_US
mus.identifier.doi10.1371/journal.pcbi.1005069en_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentMathematical Sciences.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage15en_US
mus.contributor.orcidGedeon, Tomas|0000-0001-5555-6741en_US


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