Penetration of rifampin through staphylococcus epidermidis biofilms
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Rifampin penetrated biofilms formed by Staphylococcus epidermidis but failed to effectively kill the bacteria. Penetration was demonstrated by a simple diffusion cell bioassay and by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm.
Zheng, Z. and P.S. Stewart, "Penetration of Rifampin through Staphylococcus epidermidis Biofilms," Antimicrobial Agents and Chemotherapy, 46(3):9 (2002).