Gatifloxacin efficacy in treatment of experimental methicillin-sensitive staphylococcus aureus-induced osteomyelitis in rabbits

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2002-01

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Abstract

The effectiveness of oral gatifloxacin was compared to that of standard parenteral antibiotic therapy (nafcillin) for the treatment of experimental methicillin-sensitive Staphylococcus aureus-induced osteomyelitis in a rabbit model. Gatifloxacin was as effective as nafcillin in clearing the infection. Therefore, oral gatifloxacin treatment of osteomyelitis may be an effective alternative to intravenous nafcillin treatment.

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Shirtliff, M.E., J.H. Calhoun, and J.T. Mader, "Gatifloxacin Efficacy in Treatment of Experimental Methicillin-Sensitive Staphylococcus aureus-Induced Osteomyelitis in Rabbits," Antimicrobial Agents and Chemotherapy, 46(1):2 (2002).
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