Gatifloxacin efficacy in treatment of experimental methicillin-sensitive staphylococcus aureus-induced osteomyelitis in rabbits
Shirtliff, Mark E.
Calhoun, Jason H.
Mader, Jon T.
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The effectiveness of oral gatifloxacin was compared to that of standard parenteral antibiotic therapy (nafcillin) for the treatment of experimental methicillin-sensitive Staphylococcus aureus-induced osteomyelitis in a rabbit model. Gatifloxacin was as effective as nafcillin in clearing the infection. Therefore, oral gatifloxacin treatment of osteomyelitis may be an effective alternative to intravenous nafcillin treatment.
Shirtliff, M.E., J.H. Calhoun, and J.T. Mader, "Gatifloxacin Efficacy in Treatment of Experimental Methicillin-Sensitive Staphylococcus aureus-Induced Osteomyelitis in Rabbits," Antimicrobial Agents and Chemotherapy, 46(1):2 (2002).