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dc.contributor.authorKhoury, Antoine E.
dc.contributor.authorLam, K.
dc.contributor.authorEllis, B. D.
dc.contributor.authorCosterton, J. William
dc.identifier.citationKhoury, A.E., K. Lam, B. Ellis, and J.W. Costerton, "Prevention and Control of Bacterial Infections Associated with Medical Devices," ASAIO Transactions, 38(3):M174-M178, July-September 1992.en_US
dc.description.abstractBacteria that grow in association with medical devices always form slime enclosed biofilms, within which they are protected, to a large extent, from the bactericidal activity of chemical biocides and antibiotics. Mature biofilms (>7 days) are demonstrably resistant to 500-5,000 times the concentrations of these agents than are necessary to kill free floating (planktonic) cells of the same organism. The authors have discovered that this well established inherent resistance of biofilm bacteria to antibacterial agents can be completely obviated if these agents are applied to these adherent populations within an electric field. The killing of biofilm bacteria by antibiotics can be dramatically enhanced by relatively weak electric fields (1.5 V/cm and 15 [mu]A/CM2) that, in themselves, have no deleterious effects on these slime protected populations adherent to plastic or metal surfaces. This bioelectric technology can readily be used to enhance the preimplantation sterilization of medical devices by biocides. The authors suggest that it may also be used to control biofilm formation and consequent infection by electrically enhanced perioperative antibiotic prophylaxis and by electrically enhanced penetration of antibiotics to kill the biofilm bacteria that form the inherently resistant nidus of chronic device related infections.en_US
dc.titlePrevention and control of bacterial infections associated with medical devicesen_US
mus.citation.journaltitleASAIO Transactionsen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

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