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dc.contributor.authorXie, H.
dc.contributor.authorCook, Guy S.
dc.contributor.authorCosterton, J. William
dc.contributor.authorBruce, G.
dc.contributor.authorRose, T. M.
dc.contributor.authorLamont, Richard J.
dc.identifier.citationXie, H., G.S. Cook, J.W. Costerton, G. Bruce, T.M. Rose, and R.J. Lamont, "Intergeneric Communication in Dental Plaque Biofilms," Journal of Bacteriology, 182(24):709 (2000).en_US
dc.description.abstractDental plaque is a complex biofilm that accretes in a series of discrete steps proceeding from a gram-positive streptococcus-rich biofilm to a structure rich in gram-negative anaerobes. This study investigated information flow between two unrelated plaque bacteria,Streptococcus cristatus and Porphyromonas gingivalis. A surface protein of S. cristatus caused repression of the P. gingivalisfimbrial gene (fimA), as determined by a chromosomalfimA promoter-lacZ reporter construct and by reverse transcription-PCR. Signaling activity was associated with a 59-kDa surface protein of S. cristatus and showed specificity for the fimA gene. Furthermore, P. gingivalis was unable to form biofilm microcolonies with S. cristatus. Thus, S. cristatus is capable of modulating virulence gene expression in P. gingivalis, consequently influencing the development of pathogenic plaque.en_US
dc.titleIntergeneric communication in dental plaque biofilmsen_US
mus.citation.journaltitleJournal of Bacteriologyen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

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