Modeling production of extracellular polymeric substances in a Pseudomonas aeruginosa chemostat culture
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Formation of extracellular polymeric substances (EPS) by mucoid Pseudomonas aeruginosa is investigated using literature data from chemostat cultures. The data are used to calibrate a product formation regime allowing substrate sufficient and endogenous EPS formation. Yield coefficients for both formation conditions are elucidated based on metabolic pathway analysis, Growth and non-growth related specific formation rates of respectively 0.18 g CEPS/g Ccell/h and 0.03 1/h were estimated. The exogenous and endogenous EPS yield was found to be 0.77 g CEPS/g Cglu and 0.79 g CEPS/g Ccell, respectively. Being structurally equivalent to comprehensive maintenance models, this model allows for non-growth related product formation, showing the same quality of fit as previous models restricted to exogenous EPS precursors.
Kommedal R, Bakke R, Dockery J, Stoodley P, "Modeling production of extracellular polymeric substances in a Pseudomonas aeruginosa chemostat culture," Water Science & Technology, 2001 43 (6):129-134