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dc.contributor.authorDavies, David Gwilym
dc.contributor.authorParsek, Matthew R.
dc.contributor.authorPearson, J.
dc.contributor.authorIglewski, Barbara H.
dc.contributor.authorCosterton, J. William
dc.contributor.authorGreenberg, E. P.
dc.date.accessioned2018-02-12T17:06:23Z
dc.date.available2018-02-12T17:06:23Z
dc.date.issued1998-04
dc.identifier.citationDavies DG, Parsek MR, Pearson JP, Iglewski BH, Costerton JW, Greenberg EP, "The involvement of cell-to-cell signals in the development of a bacterial biofilm," Science 1998 280(5361):295–298.en_US
dc.identifier.issn0036-8075
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/14343
dc.description.abstractBacteria in nature often exist as sessile communities called biofilms. These communities develop structures that are morphologically and physiologically differentiated from free-living bacteria. A cell-to-cell signal is involved in the development of Pseudomonas aeruginosa biofilms. A specific signaling mutant, alasI mutant, forms flat, undifferentiated biofilms that unlike wild-type biofilms are sensitive to the biocide sodium dodecyl sulfate. Mutant biofilms appeared normal when grown in the presence of a synthetic signal molecule. The involvement of an intercellular signal molecule in the development of P. aeruginosa biofilms suggests possible targets to control biofilm growth on catheters, in cystic fibrosis, and in other environments where P. aeruginosa biofilms are a persistent problem.en_US
dc.titleThe involvement of cell-to-cell signals in the development of a bacterial biofilmen_US
dc.typeArticleen_US
mus.citation.extentfirstpage295en_US
mus.citation.extentlastpage298en_US
mus.citation.issue5361en_US
mus.citation.journaltitleScienceen_US
mus.citation.volume280en_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.identifier.doi10.1126/science.280.5361.295en_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US
mus.data.thumbpage2en_US


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