Investigation of interactions between antimicrobial agents and bacterial biofilms using attenuated total reflection fourier transform infrared spectroscopy
Suci, Peter A.
Vrany, Julia Dawn
Mittelman, M. W.
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Biomaterial-centred infections are often difficult to treat. An impaired immune response, acute inflamatory reactions and the presence of recalcitrant attached microorganisms are all contributing factors. A brief review of the role of attached bacteria in biomaterial-centred infections is presented. Two major hypotheses which may explain the recalcitrance of biofilms to antimicrobial agents are discussed. The analytical capabilities of attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy for providing information on both transport of an antimicrobial agent to bacteria embedded in the biofilm and interactions between an antimicrobial agent and biofilm components are described.
Suci, P.A., J.D. Vrany, and M.W. Mittelman, “Investigation of Interactions Between Antimicrobial Agents and Bacterial biofilms Using Attenuated Total Reflection Fourier Transform Infrared Spectroscopy,” Biomaterials, 19:327-339 (1998).