Investigation of interactions between antimicrobial agents and bacterial biofilms using attenuated total reflection fourier transform infrared spectroscopy
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Date
1998-03
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Abstract
Biomaterial-centred infections are often difficult to treat. An impaired immune response, acute inflamatory reactions and the presence of recalcitrant attached microorganisms are all contributing factors. A brief review of the role of attached bacteria in biomaterial-centred infections is presented. Two major hypotheses which may explain the recalcitrance of biofilms to antimicrobial agents are discussed. The analytical capabilities of attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy for providing information on both transport of an antimicrobial agent to bacteria embedded in the biofilm and interactions between an antimicrobial agent and biofilm components are described.
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Suci, P.A., J.D. Vrany, and M.W. Mittelman, “Investigation of Interactions Between Antimicrobial Agents and Bacterial biofilms Using Attenuated Total Reflection Fourier Transform Infrared Spectroscopy,” Biomaterials, 19:327-339 (1998).