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dc.contributor.authorMushaben, M.
dc.contributor.authorUrie, R.
dc.contributor.authorFlake, T.
dc.contributor.authorJaffe, M.
dc.contributor.authorRege, K.
dc.contributor.authorHeys, Jeffrey J.
dc.identifier.citationMushaben, M., R. Urie, T. Flake, M. Jaffe, K. Rege, and Jeffrey Heys. "Spatiotemporal modeling of laser tissue soldering using photothermal nanocomposites." Lasers in Surgery and Medicine (October 2017). DOI: 10.1002/lsm.22746.en_US
dc.description.abstractOBJECTIVE: Laser tissue soldering using photothermal solders is a technology that facilitates rapid sealing using heat-induced changes in the tissue and the solder material. The solder material is made of gold nanorods embedded in a protein matrix patch that can be placed over the tissue rupture site and heated with a laser. Although laser tissue soldering is an attractive approach for surgical repair, potential photothermal damage can limit the success of this approach. Development of predictive mathematical models of photothermal effects including cell death, can lead to more efficient approaches in laser-based tissue repair. METHODS: We describe an experimental and modeling investigation into photothermal solder patches for sealing porcine and mouse cadaver intestine sections using near-infrared laser irradiation. Spatiotemporal changes in temperature were determined at the surface as well as various depths below the patch. A mathematical model, based on the finite element method, predicts the spatiotemporal temperature distribution in the patch and surrounding tissue, as well as concomitant cell death in the tissue is described. RESULTS: For both the porcine and mouse intestine systems, the model predicts temperatures that are quantitatively similar to the experimental measurements with the model predictions of temperature increase often being within a just a few degrees of experimental measurements. CONCLUSION: This mathematical model can be employed to identify optimal conditions for minimizing healthy cell death while still achieving a strong seal of the ruptured tissue using laser soldering.en_US
dc.rights"This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."en_US
dc.titleSpatiotemporal modeling of laser tissue soldering using photothermal nanocompositesen_US
mus.citation.journaltitleLasers in Surgery and Medicineen_US
mus.identifier.categoryChemical & Material Sciencesen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US

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