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dc.contributor.authorAntwi, Frank B.
dc.contributor.authorShama, Leslie M.
dc.contributor.authorPeterson, Robert K. D.
dc.date.accessioned2018-02-16T19:44:23Z
dc.date.available2018-02-16T19:44:23Z
dc.date.issued2008-06
dc.identifier.citationAntwi, Frank B., Leslie M. Shama and Robert K. D. Peterson. 2008. Risk assessments for the insect repellents DEET and Picaridin. Regulatory Toxicology and Pharmacology 51: 31-36.en_US
dc.identifier.issn0273-2300
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/14390
dc.description.abstractFor the use of topical insect repellents, DEET and picaridin, human health risk assessments were conducted for various population subgroups. Acute, subchronic, and chronic dermal exposures were examined. No-observed-effect-levels (NOELs) of 200, 300, and 100 mg/kg body weight (BW) were used as endpoints for DEET for acute, subchronic, and chronic exposures, respectively. For picaridin, a NOEL of 2000 mg/kg BW/day for acute exposure and a NOEL of 200 mg/kg BW/day for subchronic and chronic exposures were used. Daily exposures to several population subgroups were estimated. Risks were characterized using the Margin of Exposure (MOE) method (NOEL divided by the estimated exposure), whereby estimated MOEs were compared to an MOE of 100. Estimates of daily exposures ranged from 2 to 59 mg/kg BW/day for DEET and 2 to 22 mg/kg BW/day for picaridin. Children had the lowest MOEs. However, none of the estimated exposures exceeded NOELs for either repellent. At 40% DEET for acute exposure, children ⩽12 years had MOEs below 100. For subchronic and chronic exposures children at ⩾25% DEET and at 15% picaridin had MOEs below 100. Therefore, we found no significant toxicological risks from typical usage of these topical insect repellents.en_US
dc.rightsThis is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.en_US
dc.titleRisk assessments for the insect repellents DEET and Picaridinen_US
mus.citation.extentfirstpage31en_US
mus.citation.extentlastpage36en_US
mus.citation.issue1en_US
mus.citation.journaltitleRegulatory Toxicology and Pharmacologyen_US
mus.citation.volume51en_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1016/j.yrtph.2008.03.002en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.departmentLand Resources & Environmental Sciences.en_US
mus.relation.departmentResearch Centers.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupWestern Triangle Ag Research Center.en_US
mus.data.thumbpage4en_US


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