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dc.contributor.authorMailhiot, Sarah E.
dc.contributor.authorZong, Fangrong
dc.contributor.authorManeval, James E.
dc.contributor.authorGalvosas, Petrik
dc.contributor.authorSeymour, Joseph D.
dc.identifier.citationMailhiot SE, F Zong, JE Maneval, RK June, P Galvosas, JD Seymour, “Quantifying NMR relaxation correlation and exchange in articular cartilage with time domain analysis,” Journal of Magnetic Resonance. February 2018; 287:82-90. doi: 10.1016/j.jmr.2017.12.014.en_US
dc.description.abstractMeasured nuclear magnetic resonance (NMR) transverse relaxation data in articular cartilage has been shown to be multi-exponential and correlated to the health of the tissue. The observed relaxation rates are dependent on experimental parameters such as solvent, data acquisition methods, data analysis methods, and alignment to the magnetic field. In this study, we show that diffusive exchange occurs in porcine articular cartilage and impacts the observed relaxation rates in T1-T2 correlation experiments. By using time domain analysis of T2-T2 exchange spectroscopy, the diffusive exchange time can be quantified by measurements that use a single mixing time. Measured characteristic times for exchange are commensurate with T1 in this material and so impacts the observed T1 behavior. The approach used here allows for reliable quantification of NMR relaxation behavior in cartilage in the presence of diffusive fluid exchange between two environments.en_US
dc.titleQuantifying NMR relaxation correlation and exchange in articular cartilage with time domain analysisen_US
mus.citation.journaltitleJournal of Magnetic Resonanceen_US
mus.identifier.categoryEngineering & Computer Scienceen_US
mus.relation.collegeCollege of Engineeringen_US
mus.relation.departmentCenter for Biofilm Engineering.en_US
mus.relation.departmentChemical & Biological Engineering.en_US
mus.relation.departmentChemical Engineering.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.relation.researchgroupCenter for Biofilm Engineering.en_US

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