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dc.contributor.authorPlowright, Raina K.
dc.contributor.authorManlove, Kezia R.
dc.contributor.authorBesser, Thomas E.
dc.contributor.authorPaez, David J.
dc.contributor.authorAndrews, Kimberly R.
dc.contributor.authorMatthews, Patrick E.
dc.contributor.authorWaits, Lisette P.
dc.contributor.authorHudson, Peter J.
dc.contributor.authorCassirer, E. Frances
dc.date.accessioned2018-04-24T18:49:05Z
dc.date.available2018-04-24T18:49:05Z
dc.date.issued2017-09
dc.identifier.citationPlowright, Raina K., Kezia R. Manlove, Thomas E. Besser, David J. Paez, Kimberly R. Andrews, Patrick E. Matthews, Lisette P. Waits, Peter J. Hudson, and Frances E. Cassirer. "Age-specific infectious period shapes dynamics of pneumonia in bighorn sheep." Ecology Letters 20, no. 10 (September 2017): 1325-1336. DOI: 10.1111/ele.12829.en_US
dc.identifier.issn1461-0248
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/14508
dc.description.abstractSuperspreading, the phenomenon where a small proportion of individuals contribute disproportionately to new infections, has profound effects on disease dynamics. Superspreading can arise through variation in contacts, infectiousness or infectious periods. The latter has received little attention, yet it drives the dynamics of many diseases of critical public health, livestock health and conservation concern. Here, we present rare evidence of variation in infectious periods underlying a superspreading phenomenon in a free-ranging wildlife system. We detected persistent infections of Mycoplasma ovipneumoniae, the primary causative agent of pneumonia in bighorn sheep (Ovis canadensis), in a small number of older individuals that were homozygous at an immunologically relevant genetic locus. Interactions among age-structure, genetic composition and infectious periods may drive feedbacks in disease dynamics that determine the magnitude of population response to infection. Accordingly, variation in initial conditions may explain divergent population responses to infection that range from recovery to catastrophic decline and extirpation.en_US
dc.description.sponsorshipMorris Animal Foundation (D13ZO-081); National Institutes of Health (P20GM103474, P30GM110732); Montana University System Research Initiative (51040-MUSRI2015-03); Oregon Chapter of the Foundation for North American Wild Sheep;en_US
dc.titleAge-specific infectious period shapes dynamics of pneumonia in bighorn sheepen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1325en_US
mus.citation.extentlastpage1336en_US
mus.citation.issue10en_US
mus.citation.journaltitleEcology Lettersen_US
mus.citation.volume20en_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1111/ele.12829en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage3en_US


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