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dc.contributor.authorNelson, Tiffanie M.
dc.contributor.authorBorgogna, Joanna-Lynn C.
dc.contributor.authorMichalek, R. D.
dc.contributor.authorRoberts, David W.
dc.contributor.authorRath, J. M.
dc.contributor.authorGlover, E. D.
dc.contributor.authorRavel, Jacques
dc.contributor.authorShardell, M. D.
dc.contributor.authorYeoman, Carl J.
dc.contributor.authorBrotman, Rebecca M.
dc.date.accessioned2018-07-20T16:19:24Z
dc.date.available2018-07-20T16:19:24Z
dc.date.issued2018-01
dc.identifier.citationNelson, T. M., Joanna-Lynn C. Borgogna, R. D. Michalek, David W. Roberts, J. M. Rath, E. D. Glover, J. Ravel, M. D. Shardell, Carl J. Yeoman, and R. M. Brotman. "Cigarette smoking is associated with an altered vaginal tract metabolomic profile." Scientific Reports 8 (January 2018): 1-13. DOI: 10.1038/s41598-017-14943-3.en_US
dc.identifier.issn2045-2322
dc.identifier.urihttps://scholarworks.montana.edu/xmlui/handle/1/14654
dc.description.abstractCigarette smoking has been associated with both the diagnosis of bacterial vaginosis (BV) and a vaginal microbiota lacking protective Lactobacillus spp. As the mechanism linking smoking with vaginal microbiota and BV is unclear, we sought to compare the vaginal metabolomes of smokers and non-smokers (17 smokers/19 non-smokers). Metabolomic profiles were determined by gas and liquid chromatography mass spectrometry in a cross-sectional study. Analysis of the 16S rRNA gene populations revealed samples clustered into three community state types (CSTs) ---- CST-I (L. crispatus-dominated), CST-III (L. iners-dominated) or CST-IV (low-Lactobacillus). We identified 607 metabolites, including 12 that differed significantly (q-value < 0.05) between smokers and non-smokers. Nicotine, and the breakdown metabolites cotinine and hydroxycotinine were substantially higher in smokers, as expected. Among women categorized to CST-IV, biogenic amines, including agmatine, cadaverine, putrescine, tryptamine and tyramine were substantially higher in smokers, while dipeptides were lower in smokers. These biogenic amines are known to affect the virulence of infective pathogens and contribute to vaginal malodor. Our data suggest that cigarette smoking is associated with differences in important vaginal metabolites, and women who smoke, and particularly women who are also depauperate for Lactobacillus spp., may have increased susceptibilities to urogenital infections and increased malodor.en_US
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID) grants K01-AI080974 (Brotman); R21-AI111145 (Yeoman); NR015495 (Ravel); the University of Maryland Cancer Epidemiology Alliance Joint Research Pilot Granten_US
dc.rightsCC BY 4.0, This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/legalcodeen_US
dc.titleCigarette smoking is associated with an altered vaginal tract metabolomic profileen_US
dc.typeArticleen_US
mus.citation.extentfirstpage1en_US
mus.citation.extentlastpage13en_US
mus.citation.journaltitleScientific Reportsen_US
mus.citation.volume8en_US
mus.identifier.categoryHealth & Medical Sciencesen_US
mus.identifier.categoryLife Sciences & Earth Sciencesen_US
mus.identifier.doi10.1038/s41598-017-14943-3en_US
mus.relation.collegeCollege of Agricultureen_US
mus.relation.collegeCollege of Letters & Scienceen_US
mus.relation.departmentAnimal & Range Sciences.en_US
mus.relation.departmentEcology.en_US
mus.relation.departmentMicrobiology & Immunology.en_US
mus.relation.universityMontana State University - Bozemanen_US
mus.data.thumbpage3en_US
mus.contributor.orcidRoberts, David W.|0000-0001-7128-6243en_US


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CC BY 4.0, This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.
Except where otherwise noted, this item's license is described as CC BY 4.0, This license lets others distribute, remix, tweak, and build upon your work, even commercially, as long as they credit you for the original creation. This is the most accommodating of licenses offered. Recommended for maximum dissemination and use of licensed materials.

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