Synthesis and Biological Activity of Hydrazones of o- and p-Hydroxybenzoic Acids. Spatial Structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide
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2017-10
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A series of hydrazones based on hydrazides of o- and p-hydroxybenzoic acids have been prepared. N-(5-Bromo-2-hydroxybenzylidene)-4-hydroxybenzohydrazide has been studied by X-ray diffraction analysis; its molecule forms hydrogen bond with a solvating ethanol molecule. Biological activity of the synthesized hydrazones towards cathepsin E and(or) elastase of human neutrophils has been determined.
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Nurkenov, O. A. , Zh. B. Satpaeva, Igor A. Schepetkin, A. I. Khlebnikov, K. M. Turdybekov, T. M. Seilkhanov, and S. D. Fazylov. "Synthesis and Biological Activity of Hydrazones of o- and p-Hydroxybenzoic Acids. Spatial Structure of 5-Bromo-2-hydroxybenzylidene-4-hydroxybenzohydrazide." Russian Journal of General Chemistry 87, no. 10 (October 2017): 2299-2306. DOI: 10.1134/S1070363217100097.